One gene one enzyme, this is a hypothesis. It believes that one gene only help to generate one enzyme, because of which this gene determines the specificity of this enzyme and influence its phenotype. It comes from a story of G.W.Beadle and E.L.Taum in 1941.
However, there are some enzymes which are aggregated from several different polypeptides and then caused active. Now it is found that one gene can determine more than one polypeptides, and polypeptides can help to form different enzymes or be members of only one enzyme. Thus, one gene should be corresponded to one specific polypeptide, instead of one enzyme.
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