Yesterday The Molecular Systems Biology of NATURE published a paper in its News and Views column: 'Junk' DNA meets the p53 network.
The original article is addressed here.
[What is Junk-DNA]
A major part of the genome of higher eukaryotes consists of non-coding sequences. In former times, these sequences were called 'junk-DNA' as no specific function could not be attributed to them. More recent research has shown that small non-coding RNAs are contained in these parts of the genome. These non-coding RNAs have a fundamental role in gene regulation.
[What is MicroRNA(miRNA)]
MicroRNAs(miRNAs) are a relatively recently indentified means for gene regulation. They are small, endogeous non-coding RNAs, between 19 and 25 nt in length. Unlike siRNA, miRNAs are of endogenous origin and alterations in their expression are associated with a number of diseases, including cancer.
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